Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

DNA methylation-regulated ZDHHC5 and PPT1 in the pathogenesis of osteoporosis.

Medicine - 24 Apr 2026

Wang Chao, Zhu Yong, Ruan Zhe

Abstract excerpt

While osteoporosis (OP) affects over 200 million people globally, the causal roles of protein palmitoylation and its upstream epigenetic regulation in the pathogenesis of the disease remain undefined. We aimed to investigate whether DNA methylation causally influences OP risk by modulating the expression of palmitoylation-related genes. We employed an integrated multi-omics causal inference framework, combining...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acyltransferases
Share to DNA Methylation
Share to Epigenesis, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Lipoylation

Share to Mendelian Randomization Analysis

Share to Osteoporosis

Share to Quantitative Trait Loci

Share to Thiolester Hydrolases

Source

Open in PubMed Open full text

Identifiers

PMID: 42071838
DOI: 10.1097/MD.0000000000048429
PMCID: PMC13124397

Genes

ZDHHC5
PPT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

DNA methylation-regulated ZDHHC5 and PPT1 in the pathogenesis of osteoporosis.PMID 42071838Read ↗

The Palmitoyltransferases ZDHHC6 and ABHD17A Modulate Type 2 Diabetes Risk via Genetic Causality and Molecular InteractionsSemantic proximity Read ↗

Causal genes for osteoporosis: Mendelian randomization analysis with multilayer xQTL data.Semantic proximity Read ↗

PHEWAS, TWAS, Mendelian Randomization in Osteoporosis Research: the good, the bad, and the ugly.Semantic proximity Read ↗

Mediating oxidative stress through the Palbociclib/miR-141-3p/STAT4 axis in osteoporosis: a bioinformatics and experimental validation studySemantic proximity Read ↗

Identification of Potential Therapeutic Targets and Molecular Regulatory Mechanisms for Osteoporosis by Bioinformatics MethodsSemantic proximity Read ↗

Identification of Novel Potentially Pleiotropic Variants Associated With Osteoporosis and Obesity Using the cFDR Method.Semantic proximity Read ↗

Decoding the Impact of Lipid Metabolism on Osteoporosis: A Study on Phosphatidylcholine, Inflammatory Factors, and Immune CellsSemantic proximity Read ↗

Unveiling the Causal Relationship Between Osteoporosis and Circulating Metabolites from a Genetic Perspective.Semantic proximity Read ↗

Integrative Analysis of Transcriptomic and Epigenomic Data to Reveal Regulation Patterns for BMD Variation.Semantic proximity Read ↗

Single-cell and genome-wide Mendelian randomization identifies causative genes for gout.Semantic proximity Read ↗

Epigenetic analysis of Paget's disease of bone identifies differentially methylated loci that predict disease status.Semantic proximity Read ↗

Identification of biomarkers associated with diagnosis of postmenopausal osteoporosis patients based on bioinformatics and machine learningSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.