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Causes and consequences of chromosome segregation error in preimplantation embryos

6 Nov 2017

Abstract excerpt

Errors in chromosome segregation are common during the mitotic divisions of preimplantation development in mammalian embryos, giving rise to so-called 'mosaic' embryos possessing a mixture of euploid and aneuploid cells. Mosaicism is widely considered to be detrimental to embryo quality and is frequently used as criteria to select embryos for transfer in human fertility clinics. However, despite the clear...

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PMID: 29109119
DOI: 10.1530/rep-17-0569

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