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Article

Identification of macrophage polarization-related genes for esophageal cancer risk: a multi-omics Mendelian randomization analysis.

Clinical epigenetics - 6 Jun 2026

Shi Mumu, Zhou Renshi, Yu Bo, Yu Futian, Gao Jinghai

Abstract excerpt

BACKGROUND: This study aims to identify macrophage polarization (MP)-related genes implicated in esophageal cancer (EC) by integrating methylation quantitative trait loci (mQTL), expression QTL (eQTL), and protein QTL (pQTL) data with EC genome-wide association study (GWAS) data. METHODS: GWAS data were obtained from the UK Biobank for discovery and the FinnGen R10 release for validation. Blood-based mQTL, eQTL,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42251386
DOI: 10.1186/s13148-026-02171-4
PMCID: PMC13463415

Genes

LEP
INPP5D
PGF
SPP1
USP18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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