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Article

Mediating role of circulating inflammatory proteins in the effect of immune cells on esophageal cancer risk: A Mendelian randomization study.

Medicine - 1 Nov 2024

Guo Jinzhou, Si Gao, Song Xuejie, Si Fuchun

Abstract excerpt

The immune system and inflammatory processes play crucial roles in the development of esophageal cancer (EC). This study aimed to investigate the causal relationships between 731 immune cell phenotypes, 91 circulating inflammatory proteins, and EC, with a particular focus on the mediating role of circulating inflammatory proteins. Utilizing public genetic data, we applied a 2-sample Mendelian Randomization (MR)...

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Cytokines
Esophageal Neoplasms
Inflammation
Interleukin-10
Mendelian Randomization Analysis

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PMID: 39496002
DOI: 10.1097/MD.0000000000040374
PMCID: PMC11537666

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