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Article

Genetic Landscape of Acute Leukemia of Ambiguous Lineage: A Single Cancer Center Experience.

The Journal of molecular diagnostics : JMD - 1 Aug 2026

Fei Fei, Telatar Milhan, Chang Lisa, Pan Hui, Park Sunmin, Arias-Stella Javier, Tizro Parastou, Tomasian Vanina, Stein Anthony S, Stewart F Marc, Marcucci Guido, Becker Pamela S, Afkhami Michelle

Abstract excerpt

Acute leukemias of ambiguous lineage (ALALs) are rare acute leukemias with poor prognosis, encompassing acute undifferentiated leukemia and mixed-phenotype acute leukemia. The fifth edition of the World Health Organization classification of hematolymphoid tumors recommends excluding ALAL cases with myelodysplasia-associated mutations and/or cytogenetic abnormalities from classification as acute undifferentiated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42248548
DOI: 10.1016/j.jmoldx.2026.05.006

Genes

BCORL1
DNMT3A
RUNX1
TET2
TP53
WT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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