Article
MeCP2 Rett mutations affect large scale chromatin organization.
Human molecular genetics - 1 Nov 2011
Agarwal Noopur, Becker Annette, Jost K Laurence, Haase Sebastian, Thakur Basant K, Brero Alessandro, Hardt Tanja, Kudo Shinichi, Leonhardt Heinrich, Cardoso M Cristina
Abstract excerpt
Rett syndrome is a neurological, X chromosomal-linked disorder associated with mutations in the MECP2 gene. MeCP2 protein has been proposed to play a role in transcriptional regulation as well as in chromatin architecture. Since MeCP2 mutant cells exhibit surprisingly mild changes in gene expression, we have now explored the possibility that Rett mutations may affect the ability of MeCP2 to bind and organize...
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