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Article

Machine-learning prediction of affinity and epistasis in the bovine pancreatic trypsin inhibitor-chymotrypsin complex.

Protein science : a publication of the Protein Society - 1 Jul 2026

Tzuri Noam, Kass Itamar, Orenstein Yaron, Papo Niv

Abstract excerpt

Protein-protein interactions (PPIs) are shaped by evolutionary pressures that fine-tune binding affinities and drive the epistatic relationships that support functional outcomes. Here, we used the complex of bovine pancreatic trypsin inhibitor (BPTI) and chymotrypsin as a model system to study how mutations at one or two positions affect binding affinity and epistasis. To predict the binding affinity landscape of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42246481
DOI: 10.1002/pro.70660
PMCID: PMC13238754

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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