Article

Insulin resistance alters cortical inhibitory neurons and microglia to exacerbate Alzheimer’s knock-in mouse phenotypes

2025-09-11

Abstract excerpt

Metabolic dysfunction contributes to the risk and progression of Alzheimer”s disease (AD) through insulin signaling, but the cellular mechanisms are not fully understood. In this study, we examined the effects of streptozotocin-induced insulin deficiency or a high-fat, high-sugar (HFHS) diet-induced insulin resistance on cognitive function in knock-in AD mouse models expressing human mutant APP and wild-type tau....

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Literature Corpus work: ff9af67d-f20c-5fd9-b68b-fd645127cb52
DOI: 10.1101/2025.09.05.674487

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