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Article

A Single L17E Mutation Switches the Membrane Disruption Mechanism of the Spider Venom Peptide M-lycotoxin.

The journal of physical chemistry. B - 11 Jun 2026

Ohno Miki, Kawaguchi Yoshimasa, Hirose Hisaaki, Futaki Shiroh, Shinoda Wataru

Abstract excerpt

Membrane-active peptides (MAPs) disrupt lipid bilayers through mechanisms that depend sensitively on amino acid sequence, yet the molecular determinants governing membrane pore formation remain incompletely understood. The spider-venom peptide M-lycotoxin exhibits strong membrane-disruptive activity, whereas a single substitution of Leu17 with glutamate (L17E) markedly reduces cytotoxicity. Here, we employed...

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PMID: 42220253
DOI: 10.1021/acs.jpcb.6c01919

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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