Article
Genetic heterogeneity of amyotrophic lateral sclerosis: implications for clinical practice and research.
Muscle & nerve - 1 Jun 2014
Su Xiaowei W, Broach James R, Connor James R, Gerhard Glenn S, Simmons Zachary
Abstract excerpt
Genetic insights into the pathophysiology of amyotrophic lateral sclerosis (ALS) are untangling the clinical heterogeneity that may contribute to poor clinical trial outcomes and thus to a lack of effective treatments. Mutations in a large number of genes, including SOD1, C9ORF72, TARDBP, FUS, VAPB, VCP, UBQLN2, ALS2, SETX, OPTN, ANG, and SPG11, are thought to cause ALS, whereas others, including ATAXN2, GRN,...
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