Article
Rare genetic variation in UNC13A may modify survival in amyotrophic lateral sclerosis.
Amyotrophic lateral sclerosis & frontotemporal degeneration - 1 Jan 2000
Gaastra Benjamin, Shatunov Aleksey, Pulit Sara, Jones Ashley R, Sproviero William, Gillett Alexandra, Chen Zhongbo, Kirby Janine, Fogh Isabella, Powell John F, Leigh P Nigel, Morrison Karen E, Shaw Pamela J, Shaw Christopher E, van den Berg Leonard H, Veldink Jan H, Lewis Cathryn M, Al-Chalabi Ammar
Abstract excerpt
Our objective was to identify whether rare genetic variation in amyotrophic lateral sclerosis (ALS) candidate survival genes modifies ALS survival. Candidate genes were selected based on evidence for modifying ALS survival. Each tail of the extreme 1.5% of survival was selected from the UK MND DNA Bank and all samples available underwent whole genome sequencing. A replication set from the Netherlands was used for...
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