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Article

Genetic mutations in metastatic adenocarcinoma of unknown primary.

Otolaryngologia polska = The Polish otolaryngology - 1 Jun 2026

Nagano Hiromi, Kiyama Satoshi, Kyutoku Takayuki, Matsumoto Hayato, Yamashita Masaru

Abstract excerpt

INTRODUCTION: Although several genomic alterations have been reported in adenocarcinoma of unknown primary (ACUP), molecularly targeted therapies are not yet clinically established, and comprehensive genomic profiling (CGP) is rarely used in daily practice. AIM: We aimed to clarify the molecular landscape and prognostic impact of key mutations in recurrent or metastatic ACUP. MATERIALS AND METHODS: Data from 480...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42223225
DOI: 10.5604/01.3001.0055.7706

Genes

GNAS
ARID1A
NOTCH1
PIK3CA
CAT
CDKN2A
CDKN2B
ERBB2
KMT2D
KRAS
LTK
NOTCH3
STK11
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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