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Article

Genetic mutations in recurrent and/or metastatic squamous cell carcinoma of unknown primary - an analysis of the Japanese national genomic profiling database.

Otolaryngologia polska = The Polish otolaryngology - 26 Nov 2025

Nagano Hiromi, Kiyama Satoshi, Kyutoku Takayuki, Matsumoto Hayato, Yamashita Masaru

Abstract excerpt

<b>Introduction:</b> Although genetic mutations have been reported in squamous cell carcinoma of unknown primary (SCCUP), no scientifically validated targeted therapies are currently available. Moreover, cancer genomic profiling tests remain underutilized in clinical practice. These issues highlight the urgent need to elucidate the genomic landscape of SCCUP and its potential therapeutic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42138046
DOI: 10.5604/01.3001.0055.3303

Genes

BRCA2
CAT
CDKN2A
CDKN2B
KMT2D
NOTCH1
NOTCH3
PIK3CA
PTEN
RICTOR
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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