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Article

Comprehensive Genomic Profiling of Carcinoma of Unknown Primary Site: New Routes to Targeted Therapies.

JAMA oncology - 1 Apr 2015

Ross Jeffrey S, Wang Kai, Gay Laurie, Otto Geoff A, White Emily, Iwanik Kiel, Palmer Gary, Yelensky Roman, Lipson Doron M, Chmielecki Juliann, Erlich Rachel L, Rankin Andrew N, Ali Siraj M, Elvin Julia A, Morosini Deborah, Miller Vincent A, Stephens Philip J

Abstract excerpt

IMPORTANCE: For carcinoma of unknown primary site (CUP), determining the primary tumor site may be uninformative and often does not improve outcome. OBJECTIVE: To discover opportunities for targeted therapies in patients with CUP not currently searched for in routine practice. DESIGN, SETTING, AND PARTICIPANTS: Comprehensive genomic profiling on 200 CUP formalin-fixed paraffin-embedded specimens (mean, 756×...

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Identifiers

PMID: 26182302
DOI: 10.1001/jamaoncol.2014.216

Genes

BRAF
EGFR
ERBB2
KRAS
ALK
ARAF
BRCA2
FGFR1
FGFR2
KIT
MCL1
MET
MYC
NRAS
PTEN
RAF1
RET
RICTOR
ROS1
SMAD4
SMARCA4
STK11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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