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Article

Effect of Leu/Val Mutation on the Energetics of Antimicrobial Peptide:Micelle Binding.

The journal of physical chemistry. B - 21 Jul 2022

Ghosh Suvankar, Chatterjee Sunanda, Satpati Priyadarshi

Abstract excerpt

Recently, we had reported a synthetic positively charged leucine-rich 14-residue-long antimicrobial peptide (AMP, LL-14: NH3+-LKWLKKLLKWLKKL-CONH2), which was highly active and cytotoxic relative to its valine analogue (VV-14). However, the thermodynamics underlying this differential toxicity and antimicrobial activity was unclear. Understanding the energetics of peptide binding to micelles (simplest membrane...

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Anti-Infective Agents
Antimicrobial Cationic Peptides
Leucine
Micelles
Nuclear Magnetic Resonance, Biomolecular

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Phosphorylcholine

Sodium Dodecyl Sulfate

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PMID: 35815580
DOI: 10.1021/acs.jpcb.2c01293

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