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Rapid selection of a cefiderocol-resistant Escherichia coli producing NDM-5 associated with a single amino acid substitution in the CirA siderophore receptor

4 Jan 2023

Abstract excerpt

Cefiderocol is a novel siderophore-conjugated cephalosporin that is very promising for the treatment of infections caused by MDR bacteria. Its main advantages reside in its stability against MBLs for which no other commercially β-lactam can be used to date, and its uptake using the bacterial iron transport system in addition of porins.1 However, its first clinical uses also revealed acquired resistance mechanisms...

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PMID: 36864015
DOI: 10.1093/jac/dkad004

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