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Article

Cefiderocol resistance mediated by mutation of the miniconductance mechanosensitive channel MscM in Klebsiella oxytoca.

The Journal of antimicrobial chemotherapy - 3 Apr 2026

Turowski Pia, Gatermann Sören G, Pfennigwerth Niels

Abstract excerpt

OBJECTIVE: To investigate the emergence of cefiderocol resistance in a clinical Klebsiella oxytoca isolate and to identify the underlying mechanism. METHODS: A clinical isolate of K. oxytoca susceptible to cefiderocol was exposed to stepwise increasing cefiderocol concentrations via broth microdilution in iron-depleted CAMHB (ID-CAMHB) to select spontaneous mutants. WGS identified potential resistance-associated...

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PMID: 42053263
DOI: 10.1093/jac/dkag147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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