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Article

Peroxisomal DBP deficiency causes male infertility through disruption of lipid homeostasis in Drosophila.

Cellular and molecular life sciences : CMLS - 1 Jun 2026

Wang Jia, Ma Yanbin, Wang Yunbo, Zhao Jiaqi, Jin Jichen, Zhang Pengqi, Zheng Huimei, Ge Wanzhong

Abstract excerpt

Peroxisomes are essential organelles in almost all eukaryotic cells with a variety of functions in cellular metabolism, including β-oxidation of very-long-chain fatty acids (VLCFAs). Impairment in peroxisome biogenesis or single enzyme function often causes human metabolic diseases. Adult male patients with mutations in HSD17B4, which encodes for D-bifunctional protein (DBP), the central enzyme of peroxisomal...

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Source

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Identifiers

PMID: 42219416
DOI: 10.1007/s00018-026-06232-y
PMCID: PMC13433726

Genes

DBP
HSD17B4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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