Article
MFN2 Plays a Distinct Role from MFN1 in Regulating Spermatogonial Differentiation.
Stem cell reports - 12 May 2020
Chen Wei, Sun Yun, Sun Qi, Zhang Jingjing, Jiang Manxi, Chang Chingwen, Huang Xiaoli, Wang Chuanyun, Wang Pengxiang, Zhang Zhaoran, Chen Xuejin, Wang Yuan
Abstract excerpt
Although mitochondrial morphology is well-known for its role in cellular homeostasis, there is surprisingly little knowledge on whether mitochondrial remodeling is required for postnatal germ cell development. In this study, we investigated the functions of MFN1 and MFN2, two GTPases in mitochondrial fusion, during early spermatogenesis. We observed increased MFN expressions along with increased mitochondrial and...
Topics
- Animals
- Apoptosis
- Endoplasmic Reticulum Stress
- GTP Phosphohydrolases
- Infertility, Male
- Male
- Mice
- Mice, Inbred C57BL
- Mitochondria
- Mutation
- Spermatogenesis
- Spermatogonia