Novel risk loci in LGI1-antibody encephalitis: genome-wide association study discovery and validation cohorts

Abstract excerpt

Encephalitis with antibodies to leucine-rich glioma-inactivated 1 (LGI1-Ab-E) is a common form of autoimmune encephalitis, presenting with seizures and neuropsychiatric changes, predominantly in older males. More than 90% of patients carry the human leukocyte antigen (HLA) class II allele, HLA-DRB1*07:01. However, this is also present in 25% of healthy controls. Therefore, we hypothesized the presence of...

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• Autoimmune Neurological Disorders and Treatments
• Genetics and Neurodevelopmental Disorders
• Monoclonal and Polyclonal Antibodies Research