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Pre-diagnostic clonal hematopoiesis of indeterminate potential among patients with a primary cancer and risk of second cancers.

Leukemia - 1 Jun 2026

Liu Xinyuan, Adami Hans-Olov, Boberg Erik, Smedby Karin E, Wei Hui, Fang Fang, Liu Qianwei

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) is associated with an elevated risk of hematologic and solid cancers. We performed a prospective cohort study, including 63690 patients with a first diagnosis of primary cancer in the UK Biobank during 2006 to 2022, to investigate the association of pre-diagnostic CHIP with future risk of second cancers. Cox regression was employed to assess the association...

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Clonal Hematopoiesis
DNA Methyltransferase 3A
Follow-Up Studies
Hematologic Neoplasms
Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Neoplasms, Second Primary

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Identifiers

PMID: 41981103
DOI: 10.1038/s41375-026-02946-x

Genes

DNMT3A
JAK2
SRSF2
TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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