Article
Hearing loss in a whirlin mouse mutant is not reversed by activating the Whrn gene.
Hearing research - 1 Aug 2026
Pentland Daniel R, Treder Nina, Najjar Shahd, Kirwin Darcey A, Goodyear Richard, Ingham Neil J, Steel Karen P
Abstract excerpt
WHRN gene mutations underlie several forms of deafness in humans and mice. It is not known whether WHRN-associated hearing loss can be reversed after its onset and we aimed to address this using a genetic approach. We show that a knockdown mouse allele of Whrn, Whrntm1a, caused reduced transcription of Whrn and early onset recessive hearing loss. A tamoxifen-inducible Flp recombinase (Flpo) was used to remove the...
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