Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Limited Potential to Reverse Deafness Caused by Mutation of Myo7a.

Journal of the Association for Research in Otolaryngology : JARO - 1 Aug 2026

Pentland Daniel R, Blackburn Jack, Witting Lauren, Kirwin Darcey A, Steel Karen P

Abstract excerpt

PURPOSE: MYO7A is involved in several forms of deafness in humans and mice, and in this study we aimed to investigate if the hearing loss could be reversed after its onset. METHODS: A knockdown allele of Myo7a in the mouse, Myo7atm1a, was characterised by recording ABR thresholds at ages from 4 weeks to 6 months old and measuring the amount of hair cell degeneration at 4 weeks old. Scanning electron microscopy...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Deafness
Share to Evoked Potentials, Auditory, Brain Stem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hair Cells, Auditory

Share to Microscopy, Electron, Scanning

Share to Mutation

Share to Myosin VIIa

Share to Myosins

Source

Open in PubMed Open full text

Identifiers

PMID: 42010186
DOI: 10.1007/s10162-026-01050-2
PMCID: PMC7619100

Genes

ABR
MYO7A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Limited Potential to Reverse Deafness Caused by Mutation of Myo7a.PMID 42010186Read ↗

Shaker-1 mutations reveal roles for myosin VIIA in both development and function of cochlear hair cells.Semantic proximity Read ↗

Genetic Correction of Induced Pluripotent Stem Cells From a Deaf Patient With MYO7A Mutation Results in Morphologic and Functional Recovery of the Derived Hair Cell-Like Cells.Semantic proximity Read ↗

A genomic region encompassing a newly identified exon provides enhancing activity sufficient for normal myo7aa expression in zebrafish sensory hair cells.Semantic proximity Read ↗

A Myo7a mutation cosegregates with stereocilia defects and low-frequency hearing impairment.Semantic proximity Read ↗

Reversal of an existing hearing loss in <i>Spns2</i> mutant miceSemantic proximity Read ↗

Reduced climbing and increased slipping adaptation in cochlear hair cells of mice with Myo7a mutations.Semantic proximity Read ↗

Regenerating hair cells in vestibular sensory epithelia from humansSemantic proximity Read ↗

Adeno-associated viral vector administration to the inner ear and phenotype evaluation in a mouse model of hearing loss.Semantic proximity Read ↗

Mechanosensory neuron regeneration in adult <i>Drosophila</i>Semantic proximity Read ↗

Unconventional myosins and the genetics of hearing loss.Semantic proximity Read ↗

Immunohistochemistry localises myosin-7a to cochlear efferent boutonsSemantic proximity Read ↗

A mouse model for human hearing loss DFNB30 due to loss of function of myosin IIIASemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.