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Article

Auditory hair cell defects as potential cause for sensorineural deafness in Wolf-Hirschhorn syndrome.

Disease models & mechanisms - 1 Sept 2015

Ahmed Mohi, Ura Kiyoe, Streit Andrea

Abstract excerpt

WHSC1 is a histone methyltransferase (HMT) that catalyses the addition of methyl groups to lysine 36 on histone 3. In humans, WHSC1 haploinsufficiency is associated with all known cases of Wolf-Hirschhorn syndrome (WHS). The cardinal feature of WHS is a craniofacial dysmorphism, which is accompanied by sensorineural hearing loss in 15% of individuals with WHS. Here, we show that WHSC1-deficient mice display...

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Share to Cochlea
Share to Gene Deletion
Share to Hair Cells, Auditory

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hearing Loss, Sensorineural

Share to Histone-Lysine N-Methyltransferase

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Share to Receptor, Fibroblast Growth Factor, Type 3

Source

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Identifiers

PMID: 26092122
DOI: 10.1242/dmm.019547
PMCID: PMC4582100

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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