Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Transcriptional Profiling of Normal, Stenotic, and Regurgitant Human Aortic Valves

14 Jul 2020

Abstract excerpt

The genetic mechanisms underlying aortic stenosis (AS) and aortic insufficiency (AI) disease progression remain unclear. We hypothesized that normal aortic valves and those with AS or AI all exhibit unique transcriptional profiles. Normal control (NC) aortic valves were collected from non-matched donor hearts that were otherwise acceptable for transplantation (n = 5). Valves with AS or AI (n = 5, each) were...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related molecular mechanisms research
Share to Cardiac Valve Diseases and Treatments
Share to RNA modifications and cancer

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 32674273
DOI: 10.3390/genes11070789

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Transcriptional Profiling of Normal, Stenotic, and Regurgitant Human Aortic ValvesPMID 32674273Read ↗

RNA expression profile of calcified bicuspid, tricuspid, and normal human aortic valves by RNA sequencingSemantic proximity Read ↗

Clinical and Genetic insights in a tertiary care center cohort of patients with bicuspid aortic valveSemantic proximity Read ↗

Genomic and transcriptomic analyses of aortic stenosis enhance therapeutic target discovery and disease prediction.Semantic proximity Read ↗

Exploring potential genes and pathways related to calcific aortic valve diseaseSemantic proximity Read ↗

Multi-Omics Analysis of Genetic Drivers Linking Aortic Stenosis and Left Ventricular Diastolic Dysfunction in Heart FailureSemantic proximity Read ↗

Sex-specific gene expression signatures of calcific aortic valve stenosis in a large collection of human tissues.Semantic proximity Read ↗

Aortic Cellular Diversity and Quantitative Genome-Wide Association Study Trait Prioritization Through Single-Nuclear RNA Sequencing of the Aneurysmal Human AortaSemantic proximity Read ↗

Decoding causal genes and programs from regulatory variants in aortic valve diseaseSemantic proximity Read ↗

A transcriptome-wide association study identifies PALMD as a susceptibility gene for calcific aortic valve stenosis.Semantic proximity Read ↗

Comparative transcriptome profiling in human bicuspid aortic valve disease using RNA sequencingSemantic proximity Read ↗

A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profilingSemantic proximity Read ↗

Single-Cell Transcriptome Analysis Reveals Dynamic Cell Populations and Differential Gene Expression Patterns in Control and Aneurysmal Human Aortic TissueSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.