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RNA expression profile of calcified bicuspid, tricuspid, and normal human aortic valves by RNA sequencing

5 Aug 2016

Abstract excerpt

The molecular mechanisms leading to premature development of aortic valve stenosis (AS) in individuals with a bicuspid aortic valve are unknown. The objective of this study was to identify genes differentially expressed between calcified bicuspid aortic valves (BAVc) and tricuspid valves with (TAVc) and without (TAVn) AS using RNA sequencing (RNA-Seq). We collected 10 human BAVc and nine TAVc from men who...

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PMID: 27495158
DOI: 10.1152/physiolgenomics.00041.2016

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