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Associations of Baseline Clinical Phenotypes With White Matter Hyperintensity Volume Change: A Study of 4,329 UK Biobank Participants.

Neurology - 23 Jun 2026

Kancheva Angelina Kirilova, Millard Louise A C, Lyall Donald M, Wardlaw Joanna M, Quinn Terence J

Abstract excerpt

BACKGROUND AND OBJECTIVES: White matter hyperintensities (WMHs) relate to cognitive and physical impairment. Although WMHs typically progress over time, regression has also been observed. Our aim was to explore baseline clinical phenotypes associated with subsequent WMH volume change in the UK Biobank (UKB). METHODS: We included participants with total volume of WMHs at first and follow-up brain MRI. We assessed...

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PMID: 42214040
DOI: 10.1212/WNL.0000000000218085

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