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Article

ACSS2-mediated MYH9 crotonylation drives Zika virus-induced vascular smooth muscle cell phenotypic switching.

Cell reports - 23 Jun 2026

Gao Wen-Cong, Wang Bin-Bao, Yang Ren-Hua, Ma Liang, Wang Peng, Ma Xin, Yang Tie-Hua, Tan Jia-Xiang, Qiao Guan-Rong, Zhang Ding-Cheng, Yu He-Min, Jiang Ying-Jie, Zhang Hong-Ye, Zheng Yong-Tang, Chen Peng, Zheng Chang-Bo

Abstract excerpt

Zika virus (ZIKV) infection represents an emerging cause of cardiovascular pathology, yet the molecular mechanisms driving virus-induced vascular injury remain incompletely defined. This investigation identifies a crotonylation pathway underlying ZIKV-induced vascular disease. We demonstrate that ZIKV infection upregulates the metabolic regulator ACSS2, consequently elevating intracellular crotonyl-CoA levels....

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 42207636
DOI: 10.1016/j.celrep.2026.117465

Genes

ACSS2
MYH9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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