Allele-specific expression in the brain links genetic risk and cortical thinning in psychiatric disorders.

doi:10.1038/s41386-026-02439-6

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Article

Allele-specific expression in the brain links genetic risk and cortical thinning in psychiatric disorders.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Oct 2026

Akula Nirmala, Liu Siyuan, Shah Shrey, Peddada Teja Nikhil, Sung Heejong, Raznahan Armin, McMahon Francis J

Abstract excerpt

Allele-specific expression (ASE), where genetic variants exert dynamic control over gene expression, is not well studied in major psychiatric disorders. Here, we used transcriptome analysis in postmortem brain to identify genes with ASE, quantify differences in ASE in Schizophrenia (SCZ), Bipolar Disorder (BD), and Major Depressive Disorder (MDD), and explore regional relationships between differential ASE (dASE)...

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Topics

Humans
Genetic Predisposition to Disease
Female
Bipolar Disorder
Schizophrenia
Male

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

Major Depressive Disorder

Alleles

Middle Aged

Genome-Wide Association Study

Cerebral Cortex

Mental Disorders

Adult

Brain Cortical Thickness

Source

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Identifiers

PMID: 42203964
DOI: 10.1038/s41386-026-02439-6
PMCID: PMC13597493

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