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Article

The relationship between case-control differential gene expression from brain tissue and genetic associations in schizophrenia.

American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Jan 2000

Clifton Nicholas E, Schulmann Anton, Holmans Peter A, O'Donovan Michael C, Vawter Marquis P

Abstract excerpt

Large numbers of genetic loci have been identified that are known to contain common risk alleles for schizophrenia, but linking associated alleles to specific risk genes remains challenging. Given that most alleles that influence liability to schizophrenia are thought to do so by altered gene expression, intuitively, case-control differential gene expression studies should highlight genes with a higher...

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PMID: 36652379
DOI: 10.1002/ajmg.b.32931
PMCID: PMC10257740

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