Article
Regulatory Variation at TERT and TERC Shows Limited Association with Early-Onset Alzheimer's Disease in Carriers of the Mexican Founder Mutation PSEN1 A431E.
Medical sciences (Basel, Switzerland) - 30 Apr 2026
Gazcón-Rivas Celeste Patricia, Roa-Bruzón Iliannis Yisel, Duany-Almira Luis Félix, Valdéz-Gaxiola Cesar Aly, Dumois-Petersen Sofia, Figuera-Villanueva Luis Eduardo, Quintero-Ramos Antonio, Gurrola-Díaz Carmen Magdalena, Ortuño-Sahagun Daniel, Valle Yeminia, Arias-Carrión Oscar
Abstract excerpt
Background: Early-onset Alzheimer's disease (EOAD) caused by autosomal dominant mutations provides a deterministic framework for investigating genetic modifiers of neurodegeneration. Telomere biology has emerged as a central regulator of genomic stability, cellular ageing, and stress response integration, yet its role in EOAD, particularly in under-represented populations, remains poorly defined. Methods: We...
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