Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

THOP1 Is Entailed in a Genetic Fingerprint Associated with Late-Onset Alzheimer's Disease.

Biomolecules - 26 Feb 2025

Climer Sharlee

Abstract excerpt

In a systematic explorative study of genetic patterns on chromosome 19, we discovered a pattern comprising 23 SNP alleles that is significantly associated with late-onset Alzheimer's disease (AD). This association was validated using two independent datasets. The pattern includes thimet oligopeptidase (THOP1), which has a long and disputatious relationship with AD. It also spans solute carrier family 39 member 3...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Aged
Share to Alleles

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Alzheimer Disease

Share to Genetic Predisposition to Disease

Share to Metalloendopeptidases

Share to Polymorphism, Single Nucleotide

Source

Open in PubMed Open full text

Identifiers

PMID: 40149871
DOI: 10.3390/biom15030337
PMCID: PMC11939865

Genes

THOP1
DIRAS1
SLC39A3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

THOP1 Is Entailed in a Genetic Fingerprint Associated with Late-Onset Alzheimer's Disease.PMID 40149871Read ↗

THOP1 Is Entailed in a Genetic Fingerprint Associated with Late-Onset Alzheimer’s DiseaseSemantic proximity Read ↗

On the effect heterogeneity of established disease susceptibility loci for Alzheimer's disease across different genetic ancestries.Semantic proximity Read ↗

GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease.Semantic proximity Read ↗

Follow-up of loci from the International Genomics of Alzheimer's Disease Project identifies TRIP4 as a novel susceptibility gene.Semantic proximity Read ↗

An inherited variable poly-T repeat genotype in TOMM40 in Alzheimer disease.Semantic proximity Read ↗

Associations Between Genetic Variants in 19p13 and 19q13 Regions and Susceptibility to Alzheimer Disease: A Meta-Analysis.Semantic proximity Read ↗

A primate-specific (CCG) repeat in DISP2 is subject to natural selection in human and harbors divergent genotypes in late-onset neurocognitive disorder.Semantic proximity Read ↗

Genetic variation at a single locus and age of onset for Alzheimer's disease.Semantic proximity Read ↗

Intermediate repeat expansions of TBP and STUB1: Genetic modifier or pure digenic inheritance in spinocerebellar ataxias?Semantic proximity Read ↗

Regulatory Variation at TERT and TERC Shows Limited Association with Early-Onset Alzheimer's Disease in Carriers of the Mexican Founder Mutation PSEN1 A431E.Semantic proximity Read ↗

A GCC repeat in RAB26 undergoes natural selection in human and harbors divergent genotypes in late-onset Alzheimer's disease.Semantic proximity Read ↗

Late-onset Alzheimer's disease is associated with mitochondrial DNA 7028C/haplogroup H and D310 poly-C tract heteroplasmySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.