Article
Common variants near TERC are associated with mean telomere length.
Nature genetics - 1 Mar 2010
Codd Veryan, Mangino Massimo, van der Harst Pim, Braund Peter S, Kaiser Michael, Beveridge Alan J, Rafelt Suzanne, Moore Jasbir, Nelson Chris, Soranzo Nicole, Zhai Guangju, Valdes Ana M, Blackburn Hannah, Mateo Leach Irene, de Boer Rudolf A, Kimura Masayuki, Aviv Abraham, Goodall Alison H, Ouwehand Willem, van Veldhuisen Dirk J, van Gilst Wiek H, Navis Gerjan, Burton Paul R, Tobin Martin D, Hall Alistair S, Thompson John R, Spector Tim, Samani Nilesh J
Abstract excerpt
We conducted genome-wide association analyses of mean leukocyte telomere length in 2,917 individuals, with follow-up replication in 9,492 individuals. We identified an association with telomere length on 3q26 (rs12696304, combined P = 3.72 x 10(-14)) at a locus that includes TERC, which encodes the telomerase RNA component. Each copy of the minor allele of rs12696304 was associated with an approximately...
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