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Article

A fully next-generation sequencing-based method of classifying molecular sub-types of endometrial cancer retains prognostic value and expands biomarker targets.

International journal of gynecological cancer : official journal of the International Gynecological Cancer Society - 1 Feb 2025

Valentine Mark C, Wong Amanda, Chen Ling, Du Feiyu, Hughes Andrew E O, Spencer David H, Duncavage Eric J, Sun Lulu

Abstract excerpt

OBJECTIVE: The molecular classification of endometrial cancer into POLE-ultra-mutated, mismatch repair-deficient, p53-mutated, and no specific molecular profile sub-types has significant prognostic value and is recommended in the evaluation of all patients with endometrial cancer. Nonetheless, there has been inconsistent clinical implementation. One possible barrier is the current practice of using several...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 39971443
DOI: 10.1016/j.ijgc.2024.100060
PMCID: PMC13051393

Genes

POLE
CTNNB1
ERBB2

Provenance

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