Interpretation strategy of POLE, mismatch repair deficiency, and p53 in the multiple molecular classification of endometrial carcinoma and its clinical differences from single classification: a retrospective cohort study.

Abstract excerpt

OBJECTIVE: The 2023 FIGO staging system and current European guidelines incorporate four molecular classes of endometrial carcinoma: POLEmut, MMRd, p53abn, and NSMP. Tumours harboring multiple classifying alterations require hierarchical interpretation. This study evaluated the clinical impact of resolving multiple-classifier tumours according to the hierarchy POLEmut > MMRd > p53abn. STUDY DESIGN: We...

Topics

• Humans
• Endometrial Neoplasms
• Female
• Retrospective Studies
• Tumor Suppressor Protein p53
• DNA Polymerase II
• DNA Mismatch Repair
• Middle Aged
• Poly-ADP-Ribose Binding Proteins