Interpretation strategy of POLE, mismatch repair deficiency, and p53 in the multiple molecular classification of endometrial carcinoma and its clinical differences from single classification: a retrospective cohort study.

Abstract excerpt

OBJECTIVE: The 2023 FIGO staging system and current European guidelines incorporate four molecular classes of endometrial carcinoma: POLEmut, MMRd, p53abn, and NSMP. Tumours harboring multiple classifying alterations require hierarchical interpretation. This study evaluated the clinical impact of resolving multiple-classifier tumours according to the hierarchy POLEmut > MMRd > p53abn. STUDY DESIGN: We...

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