Article
Identification of molecular subtypes for endometrial carcinoma using a 46-gene next-generation sequencing panel: a retrospective study on a consecutive cohort.
ESMO open - 1 Oct 2024
Guo Q, Tang S, Ju X, Feng Z, Zhang Z, Peng D, Liu F, Du H, Wang J, Zhang Y, Wang G, Zhang Z, Cai S, Diao Y, Zhong Y, Wu X, Zhou X, Wen H
Abstract excerpt
BACKGROUND: Traditional classification tools for endometrial carcinoma (EC), such as DNA sequencing, immunohistochemistry (IHC), or PCR, are cumbersome and time-consuming. Large next-generation sequencing (NGS) panels have simplified testing but are expensive. In this study, we propose a concise NGS panel as an effectively viable approach for classifying EC. MATERIALS AND METHODS: We retrospectively enrolled a...
Topics
- Humans
- Female
- Endometrial Neoplasms
- Retrospective Studies
- High-Throughput Nucleotide Sequencing
- Middle Aged
- Aged
- Adult
- Mutation
- Microsatellite Instability