Article
Utility of a custom designed next generation DNA sequencing gene panel to molecularly classify endometrial cancers according to The Cancer Genome Atlas subgroups.
BMC medical genomics - 30 Nov 2020
Miller Eirwen M, Patterson Nicole E, Gressel Gregory M, Karabakhtsian Rouzan G, Bejerano-Sagie Michal, Ravi Nivedita, Maslov Alexander, Quispe-Tintaya Wilber, Wang Tao, Lin Juan, Smith Harriet O, Goldberg Gary L, Kuo Dennis Y S, Montagna Cristina
Abstract excerpt
BACKGROUND: The Cancer Genome Atlas identified four molecular subgroups of endometrial cancer with survival differences based on whole genome, transcriptomic, and proteomic characterization. Clinically accessible algorithms that reproduce this data are needed. Our aim was to determine if targeted sequencing alone allowed for molecular classification of endometrial cancer. METHODS: Using a custom-designed 156 gene...
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