Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic Determinants of Stress Reactivity in Pregnancy: A Systematic Review and Meta-Analysis: Implications for Maternal and Fetal Health.

Genes - 25 Apr 2026

Ioana Denisa Socol, George Socol Flavius, Sorina Farcaș Simona, Bogdan-Ionel Dumitriu, Alina-Iasmina Dumitriu, Andreea Antal, Aris Boarta, Daniela Iacob, Ioana Andreescu Nicoleta

Abstract excerpt

Background: Gestation is a period of significant biological plasticity where the intrauterine environment influences fetal development via "fetal programming". This study systematically reviews and meta-analyzes the association between genetic determinants-specifically the NR3C1, FKBP5, and CRHR1 genes, chosen for their pivotal role in the functional regulation and feedback sensitivity of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CRF Receptor, Type 1
Share to Fetal Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hypothalamo-Hypophyseal System

Share to Pituitary-Adrenal System

Share to Receptors, Corticotropin-Releasing Hormone

Share to Receptors, Glucocorticoid

Share to Stress, Psychological

Share to Tacrolimus Binding Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 42194966
DOI: 10.3390/genes17050509
PMCID: PMC13206427

Genes

FKBP5
NR3C1
CRHR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic Determinants of Stress Reactivity in Pregnancy: A Systematic Review and Meta-Analysis: Implications for Maternal and Fetal Health.PMID 42194966Read ↗

Placental epigenetic signatures of maternal distress in glucocorticoid-related genes and newborn outcomes: A study of Spanish primiparous womenSemantic proximity Read ↗

Does Prenatal Stress Shape Postnatal Resilience? – An Epigenome-Wide Study on Violence and Mental Health in HumansSemantic proximity Read ↗

Distress During Pregnancy: Epigenetic Regulation of Placenta Glucocorticoid-Related Genes and Fetal NeurobehaviorSemantic proximity Read ↗

Differential impact of prenatal PTSD symptoms and preconception trauma exposure on placental NR3C1 and FKBP5 methylationSemantic proximity Read ↗

Maternal mental well-being during pregnancy and glucocorticoid receptor gene promoter methylation in the neonateSemantic proximity Read ↗

Genetic variants in the genes of the stress hormone signalling pathway and depressive symptoms during and after pregnancy.Semantic proximity Read ↗

Risk and resilience: genetic and environmental influences on development of the stress response.Semantic proximity Read ↗

Genetic variants in the glucocorticoid pathway genes and birth weight.Semantic proximity Read ↗

Placental FKBP5 genetic and epigenetic variation is associated with infant neurobehavioral outcomes in the RICHS cohort.Semantic proximity Read ↗

Prenatal maternal stress, fetal programming, and mechanisms underlying later psychopathology—A global perspectiveSemantic proximity Read ↗

The Epigenetic Link between Prenatal Adverse Environments and Neurodevelopmental DisordersSemantic proximity Read ↗

Personality vulnerability to depression, resilience, and depressive symptoms: epigenetic markers among perinatal womenSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.