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Placental epigenetic signatures of maternal distress in glucocorticoid-related genes and newborn outcomes: A study of Spanish primiparous women

5 Nov 2024

Abstract excerpt

• Early pregnancy cortisol may induce DNA methylation changes in the chorionic villi. • The placenta is more sensitive to stress during earlier stages of pregnancy. • Depressive symptoms should be assessed across pregnancy, particularly during its earlier stages. • Early delivery is associated with increased FKBP5 methylation in the maternal decidua. • HSD11B2 was hypomethylated in both placental layers. Maternal...

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PMID: 39504602
DOI: 10.1016/j.euroneuro.2024.10.001

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