Placental epigenetic signatures of maternal distress in glucocorticoid-related genes and newborn outcomes: A study of Spanish primiparous women

Abstract excerpt

• Early pregnancy cortisol may induce DNA methylation changes in the chorionic villi. • The placenta is more sensitive to stress during earlier stages of pregnancy. • Depressive symptoms should be assessed across pregnancy, particularly during its earlier stages. • Early delivery is associated with increased FKBP5 methylation in the maternal decidua. • HSD11B2 was hypomethylated in both placental layers. Maternal...