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Article

Placental FKBP5 genetic and epigenetic variation is associated with infant neurobehavioral outcomes in the RICHS cohort.

PloS one - 1 Jan 2014

Paquette Alison G, Lester Barry M, Koestler Devin C, Lesseur Corina, Armstrong David A, Marsit Carmen J

Abstract excerpt

Adverse maternal environments can lead to increased fetal exposure to maternal cortisol, which can cause infant neurobehavioral deficits. The placenta regulates fetal cortisol exposure and response, and placental DNA methylation can influence this function. FK506 binding protein (FKBP5) is a negative regulator of cortisol response, FKBP5 methylation has been linked to brain morphology and mental disorder risk,...

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Source

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Identifiers

PMID: 25115650
DOI: 10.1371/journal.pone.0104913
PMCID: PMC4130612

Genes

FKBP5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Placental FKBP5 genetic and epigenetic variation is associated with infant neurobehavioral outcomes in the RICHS cohort.PMID 25115650Read ↗

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