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Article

Targeting arginine metabolism reverses bone immunosuppressive microenvironment and metastasis in ARID1A-deficient triple negative breast cancer.

Nature communications - 26 May 2026

Pan Shuangyue, Wang Jinyan, Wang Boya, Wang Fangqian, Chen Qingjian, Liu Tiantian, Zhang Aima, Wu Shenyuqi, Li Bin, Hu Hai, Yang Mengdi, Tao Zhonghua, Hu Xichun

Abstract excerpt

Bone metastasis is a lethal consequence of breast cancer. AT-rich interaction domain 1 A gene (ARID1A), a subunit of the switch/sucrose non-fermentable (SWI/SNF) complex, regulates immunosuppressive tumor microenvironment. However, its specific role in bone metastasis remains unclear. Here, we show that female patients with ARID1A‑mutated triple negative breast cancer (TNBC) exhibit a higher bone metastasis...

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Source

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Identifiers

PMID: 42191692
DOI: 10.1038/s41467-026-73574-3
PMCID: PMC13389217

Genes

ARID1A
ARG2
ODC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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