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Article

Structure-Guided Development of Genotype-Specific Recombinant Antibodies for Rapid Norovirus Detection via Dual-Mode Immunoassays.

Analytical chemistry - 9 Jun 2026

Wei Chunhao, Ji Bin, Lu Mingyan, Xu Xinxin, Liu Liqiang, Wu Aihong, Xu Chuanlai, Kuang Hua, Qu Aihua

Abstract excerpt

Norovirus (NoV) is a leading cause of acute gastroenteritis. We expressed GI.1 and GII.4 VP1 proteins and generated genotype-specific monoclonal antibodies (1C1 for GI.1; 7B5 and 10B8 for GII.4). Variable heavy chains and variable light chains were obtained, and full-length heavy/light chain vectors were constructed. Recombinant antibodies (rAbs) expressed in Expi293F and ExpiCHO cells showed an affinity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 42187137
DOI: 10.1021/acs.analchem.6c02265

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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