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Article

Role of Brown Adipose Tissue-Specific Sympathetic and Sensory Innervations in Menthol-Induced Energy-Expending Phenotype.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 31 May 2026

Lal Roshan, Soni Neha, Agarwal Kushhagra, Kondepudi Kanthi Kiran, Khare Pragyanshu, Zimmermann Katharina, Karbownik-Lewińska Małgorzata, Gesing Adam, Aggarwal Vaishali, Chopra Kanwaljit, Bishnoi Mahendra

Abstract excerpt

Menthol, a TRPM8 agonist and pharmacological cold mimic, activates brown adipose tissue (BAT) to increase adaptive thermogenesis and whole-body energy expenditure. BAT is highly innervated with sensory and sympathetic nerve fibers. There is existing literature that sympathetic nerves have a critical role in regulating menthol's (or cold) effect on energy homeostasis, but there is minimal literature about the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 42186762
DOI: 10.1096/fj.202600519RRRR

Genes

TRPM8

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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