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Article

Regional heterogeneity in phenotypic and genetic associations between bone and brain in humans.

Nature communications - 25 May 2026

Zhao Lei, Tang Yilan, Zhao Wenhui, Li Shijiani, Chen Jie, Ge Tian, Tu Yiheng

Abstract excerpt

The co-occurrence of skeletal and neuropsychiatric disorders suggests underlying bone-brain associations, yet their characterization remains limited by the anatomical and biological complexity of both systems. Here, we systematically examine these associations across diverse anatomical locations using structural imaging and genetic data from approximately 45,000 UK Biobank participants. We identify widespread...

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Identifiers

PMID: 42185266
DOI: 10.1038/s41467-026-73428-y
PMCID: PMC13385815

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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