Article
The molecular genetic landscape of human brain size variation.
Cell reports - 28 Nov 2023
Seidlitz Jakob, Mallard Travis T, Vogel Jacob W, Lee Younga H, Warrier Varun, Ball Gareth, Hansson Oskar, Hernandez Leanna M, Mandal Ayan S, Wagstyl Konrad, Lombardo Michael V, Courchesne Eric, Glessner Joseph T, Satterthwaite Theodore D, Bethlehem Richard A I, Bernstock Joshua D, Tasaki Shinya, Ng Bernard, Gaiteri Chris, Smoller Jordan W, Ge Tian, Gur Raquel E, Gandal Michael J, Alexander-Bloch Aaron F
Abstract excerpt
Human brain size changes dynamically through early development, peaks in adolescence, and varies up to 2-fold among adults. However, the molecular genetic underpinnings of interindividual variation in brain size remain unknown. Here, we leveraged postmortem brain RNA sequencing and measurements of brain weight (BW) in 2,531 individuals across three independent datasets to identify 928 genome-wide significant...
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