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Article

Opioid use disorder and dementia risk: evidence from observational and genetic analyses in diverse ancestry cohorts.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2026

Javidnia Sara, Roe James M, Karhunen Ville, Gill Dipender, Bell Steven, Deak Joseph D, Levey Daniel, Kember Rachel L, Kranzler Henry R, Cronjé Héléne Toinét, Burgess Stephen, Gelernter Joel, Ebmeier Klaus P, Topiwala Anya

Abstract excerpt

INTRODUCTION: Opioid use disorder (OUD) may adversely affect brain health, but its role in dementia risk remains poorly understood. METHODS: We investigated associations between OUD and dementia using observational data from 222,518 participants (European and African ancestry) in the Million Veteran Program and Mendelian randomization (MR) using genome-wide association study summary statistics from 6,066,918...

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Identifiers

PMID: 42170857
DOI: 10.1002/alz.71418
PMCID: PMC13240559

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