Transglutaminase Type 2-MITF axis regulates phenotype switching in skin cutaneous melanoma.

doi:10.1038/s41419-023-06223-y

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Transglutaminase Type 2-MITF axis regulates phenotype switching in skin cutaneous melanoma.

Cell death & disease - 28 Oct 2023

Muccioli Silvia, Brillo Valentina, Varanita Tatiana, Rossin Federica, Zaltron Elisabetta, Velle Angelo, Alessio Giorgia, Angi Beatrice, Severin Filippo, Tosi Anna, D'Eletto Manuela, Occhigrossi Luca, Falasca Laura, Checchetto Vanessa, Ciaccio Roberto, Fascì Amelia, Chieregato Leonardo, Rebelo Ana Paula, Giacomello Marta, Rosato Antonio, Szabò Ildikò, Romualdi Chiara, Piacentini Mauro, Leanza Luigi

Abstract excerpt

Skin cutaneous melanoma (SKCM) is the deadliest form of skin cancer due to its high heterogeneity that drives tumor aggressiveness. Melanoma plasticity consists of two distinct phenotypic states that co-exist in the tumor niche, the proliferative and the invasive, respectively associated with a high and low expression of MITF, the master regulator of melanocyte lineage. However, despite efforts, melanoma research...

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Identifiers

PMID: 37898636
DOI: 10.1038/s41419-023-06223-y
PMCID: PMC10613311

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