Effects of the Y432S Cancer-Associated Variant on the Reaction Mechanism of Human DNA Polymerase κ.

Abstract excerpt

Human DNA polymerases are vital for genetic information management. Their function involves catalyzing the synthesis of DNA strands with unparalleled accuracy, which ensures the fidelity and stability of the human genomic blueprint. Several disease-associated mutations and their functional impact on DNA polymerases have been reported. One particular polymerase, human DNA polymerase kappa (Pol κ), has been...

Topics

• Humans
• Molecular Dynamics Simulation
• DNA-Directed DNA Polymerase
• Neoplasms
• Quantum Theory
• Mutation
• Thermodynamics
• Catalytic Domain
• Protein Conformation