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Article

Bile acid-mediated inhibition of C. difficile by P. hiranonis revealed through a ΔbaiCD mutant.

Anaerobe - 1 Sept 2026

von Emloh Louise, Ingle Patrick, Volet Colin, Vico-Oton Eduard, Bernier-Latmani Rizlan, Winzer Klaus, Minton Nigel

Abstract excerpt

OBJECTIVES: The biotransformation of primary to secondary bile acids via 7α-dehydroxylation is key in the onset of C. difficile-associated disease, due to their role in the germination and outgrowth of spores in the gut. Clostridium scindens, a gut commensal, has been implicated in bile acid-mediated colonisation resistance against C. difficile, but research has been hindered by its genetic intractability. Here...

Read the complete abstract on PubMed

Topics

Clostridioides difficile
Bile Acids and Salts
Biotransformation
Bacterial Proteins
Eubacteriales
Gene Deletion

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Identifiers

PMID: 42162777
DOI: 10.1016/j.anaerobe.2026.103054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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