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Strain-dependent induction of primary bile acid 7-dehydroxylation by cholic acid

1 Aug 2024

Abstract excerpt

BACKGROUND: Bile acids (BAs) are steroid-derived molecules with important roles in digestion, the maintenance of host metabolism, and immunomodulation. Primary BAs are synthesized by the host, while secondary BAs are produced by the gut microbiome through transformation of the former. The regulation of microbial production of secondary BAs is not well understood, particularly the production of 7-dehydroxylated...

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PMID: 39090543
DOI: 10.1186/s12866-024-03433-y

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